Services

The Structural Biology Facility occupies about 3000 sq. ft. in the Scott Research Tower it offers three main services:

  • Protein Expression and Purification (PrEP) – The PrEP service is dedicated to the high yield production, purification and labeling of protein which is used by investigators for a wide range of purposes.
  • Crystal Screening and Growth (CSG) – The CSG service uses the Formulatrix Rockmaker LIMS and associated robotic instrumentation to guide the crystallization of proteins of interest.
  • X-ray – The X-ray service has single crystal diffractometer for solving high resolution X-ray crystal structures.  The system consists of an FRE+ rotating copper anode generator, high resolution optics, quarter-chi goniometer, and an R-Axis IV++ detector.  The service also has a Rigaku BioSAXS-1000 to collect Small Angle X-ray Scattering (SAXS) data on solutions.

The Eppley Structural Biology Facility is equipped with the latest industry standard equipment to create large amounts of extremely pure protein for a variety of uses as well as the equipment to collect and solve atomic resolution structures using X-ray Crystallography.