The Structural Biology Facility occupies about 3000 sq. ft. in the Scott Research Tower and the Eppley Science Hall it offers four main services:

  • Protein Expression and Purification (PrEP) – The PrEP service is dedicated to the high yield production, purification and labeling of protein which is used by investigators for a wide range of purposes.
  • Crystal Screening and Growth (CSG) – The CSG service uses the Formulatrix Rockmaker LIMS and associated robotic instrumentation to guide the crystallization of proteins of interest.
  • X-ray – The X-ray service has single crystal diffractometer for solving high resolution X-ray crystal structures.  The system consists of an FRE+ rotating copper anode generator, high resolution optics, quarter-chi goniometer, and an R-Axis IV++ detector.  The service also has a Rigaku BioSAXS-1000 to collect Small Angle X-ray Scattering (SAXS) data on solutions.
  • Nuclear Magnetic Resonance (NMR) – The NMR service operates three spectrometers (400, 500 and 600 Mhz) allowing it to perform a wide variety of NMR data collection including solving protein structures up to 30 kDa.

The Eppley Structural Biology Facility is equipped with the latest industry standard equipment to create large amounts of extremely pure protein for a variety of uses as well as the equipment to collect and solve atomic resolution structures using X-ray Crystallography or NMR.